3 Arumugam et al (159-176)
نویسنده
چکیده
Mycobacterium leprae (M. leprae) as alternative to current WHO MDT. Individual drugs tested were Rifampicin (RMP), Rifapentine (RPT) and Moxifloxacin (MOXI). Drug combinations were RMP, Clarithromycin (CLARI), Minocycline (MINO) and RMP, MINO and Ofloxacin (OFLO). RPT drug combinations were RPT, CLARI, MINO and RPT, OFLO, MINO. Both the drugs and drug combinations were used as daily regimen and intermittent regimen. WHO MB MDT served as a positive control. Mice pre-inoculated with M. leprae were allotted to daily and intermittent groups and administered selected drugs and drug combinations. At the end of 12 months post sub-inoculation, mice were sacrificed and the proportion % of viable bacilli were counted using Spearman and Karber method. It was noted that RMP, RPT and Moxifloxacin indicated a range of 89.99% to 99.99% bactericidal effect when used in daily or intermittent doses in both normal and TR mice. Drug combinations showed bactericidal effect comparable to that of WHO MDT. From the study it was concluded that if the present duration of MDT has to be shortened then daily dose regimen with RMP/MINO/OFLO or RPT/CLARI/MINO are recommended for a clinical trial.
منابع مشابه
Correction: Towards improved precision in the quantification of surface-enhanced Raman scattering (SERS) enhancement factors: a renewed approach.
Correction for 'Towards improved precision in the quantification of surface-enhanced Raman scattering (SERS) enhancement factors: a renewed approach' by Arumugam Sivanesan et al., Analyst, 2015, DOI:10.1039/c4an01778a
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[1] Enger, P. O. et al. Hum.Gene Ther. 2002; 13: 1115–1125. [2] Kirn, D. et al. Nat.Med. 2001; 7: 781–787. [3] Haviv, Y. S. et al. Adv.Drug Deliv.Rev. 2001; 53: 135–154. [4] Siders, W. M. et al. Cancer Gene Ther. 1998; 5: 281–291. [5] Rots, M. G. et al. J.Control Release 2003; 87: 159–165. [6] Schaack, J. et al. Proc.Natl.Acad.Sci.U.S.A 1996; 93: 14686–14691. [7] Balzar, M. et al. J.Mol.Med. 19...
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